The fluorination of 2,4,5-trichloro-6-methylpyrimidine; Experimental study and CNDO/2 calculation

doi:10.1016/S0022-1139(00)85019-8

Paper

The fluorination of 2,4,5-trichloro-6-methylpyrimidine; Experimental study and CNDO/2 calculation

Published Mar 1, 1987 · T. Wei, Zhao Yi-Xing, Zhu Zheng-hua

Journal of Fluorine Chemistry

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7

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

The fluorination of 2,4,5-trichloro-6-methylpyrimidine in polar aprotic solvents with KF or NaF is a pseudo-first-order consecutive reaction, influenced by solvents, catalysts, and fluorinating agents.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

The fluorination of 2,4,5-trichloro-6-methylpyrimidine; Experimental study and CNDO/2 calculation

References

Fluorinated heterocyclic compounds: Selective chlorine/fluorine exchange reactions on pyrimidines

Selective chlorine/fluorine exchange reactions on pyrimidines reveal that sodium and potassium fluoride fluorinate only in the heterocyclic nucleus, hydrogen fluoride in the nucleus and chlorinated methyl group, and antimony trifluoride in the chlorinated methyl group.

Empirical Parameters of Solvent Polarity as Linear Free‐Energy Relationships

Empirical parameters of solvent polarity can help quantify solvent effects on chemical reactions and provide a reliable method for predicting solvent effects.

Theory of the Influence of the Dielectric Constant on the Rate of Reaction in Solution with Application to Enzyme Reactions. I. Development of the Theory and its Application to Some Simple Systems

The developed theory predicts a linear relationship between reaction rate and solvent dielectric constant, with potential applications in enzyme reactions and other systems with arbitrary charge distributions.

Citations

Fluorine Containing Diazines. Synthesis and Properties

This review highlights significant advancements in the synthesis and properties of fluorinated pyrimidine, pyrazine, and pyridazine, focusing on ring- and chain-fluorinated diazines.

Fluorine in Heterocyclic Chemistry Volume 2: 6-Membered Heterocycles

Fluorinated and -pyrones, chromones, and coumarins are attractive building blocks for the synthesis of various heterocyclic compounds containing the R F group.

Fluorine-Containing Dyes

Fluorine-containing reactive dyes have become an increasingly important part of the cotton dye market, accounting for 15-20% of total consumption in 1990, with their global sales estimated at 10,000 tonnes.

Recent advances in fluoroheterocyclic chemistry

Polyfluoroheterocycles have potential applications in agrochemicals, fiber-reactive dyes, and optical clarity, with potential for use in fiber-reactive dyes and polyfluoroheterocycle-based polymers.

Halogenation of Heterocycles: II. Six- and Seven-Membered Rings

Halogenation of aromatic heterocycles can produce chlorinated derivatives, with activating groups like N-oxide functions aiding in some processes.