Anticonvulsants that induce hepatic metabolism increase clearance of oral contraceptive hormones and thereby cause contraceptive failure. Gabapentin is not metabolized in humans and has little liability for causing metabolic-based drug-drug interactions. In healthy women receiving 2.5 mg norethindrone acetate and 50 µg ethinyl estradiol daily for three consecutive menstrual cycles, concurrent gabapentin administration did not alter the steady-state pharmacokinetics of either hormone. Thus, gabapentin is unlikely to cause contraceptive failure.

Gabapentin does not interact with a contraceptive regimen of norethindrone acetate and ethinyl estradiol, making it unlikely to cause contraceptive failure.

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Gabapentin does not interact with a contraceptive regimen of norethindrone acetate and ethinyl estradiol

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