Efficient and General Protocol for Sonogashira Cross‐Coupling Reactions of Maleimides

doi:10.1002/EJOC.201101811

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Efficient and General Protocol for Sonogashira Cross‐Coupling Reactions of Maleimides

Agathe Souffrin, C. Croix, M. Viaud-Massuard

May 1, 2012

Citations

Journal

European Journal of Organic Chemistry

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Key Takeaway

Key Takeaway: Sonogashira cross-coupling reactions of maleimides allow for efficient synthesis of various difunctionalized maleimide derivatives at room temperature in moderate to excellent yields.

Abstract

Maleimides are involved for the first time in Sonogashira cross-coupling reactions. Sonogashira conditions have been developed to allow subsequent coupling of various terminal alkynes at room temperature in moderate to excellent yields. These results open the way to innovative synthesis strategies for various difunctionalized maleimide derivatives.

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