Agathe Souffrin, C. Croix, M. Viaud-Massuard
May 1, 2012
European Journal of Organic Chemistry
Maleimides are involved for the first time in Sonogashira cross-coupling reactions. Sonogashira conditions have been developed to allow subsequent coupling of various terminal alkynes at room temperature in moderate to excellent yields. These results open the way to innovative synthesis strategies for various difunctionalized maleimide derivatives.