New groups of potential antituberculotics : 3-aryl-2H,4H-benz[e][1,3]oxazine-2,4-diones. Comparison of the topliss approach with regression analysis

doi:10.1135/CCCC19932977

Paper

New groups of potential antituberculotics : 3-aryl-2H,4H-benz[e][1,3]oxazine-2,4-diones. Comparison of the topliss approach with regression analysis

Published 1993 · K. Waisser, L. Kubicová, V. Klimešová

Collection of Czechoslovak Chemical Communications

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Abstract

3-Phenyl-2 H ,4 H -benz[ e ][1,3]oxazine-2,4-dione ( I ) and its derivatives II - XI , substituted on the phenyl ring, can be regarded as a new group of potential antituberculotics. Their activity increases with increasing electron-accepting properties of the substituents. introduction of bromine into the position 6 also positively influences the activity. the compounds are active in vitro against Mycobacterium tuberculosis and M. kansasii . The activity of some of them ( VIII, IX 0 exceeds that of commercial tuberculostatics used as standards.

In Vitro Study

Study Snapshot

3-Phenyl-2H,4H-benz[e][1,3]oxazine-2,4-diones show potential as new antituberculotics, with activity increasing with electron-accepting properties and bromine introduction, and some showing activity exceeding commercial tuberculostatics.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

New groups of potential antituberculotics : 3-aryl-2H,4H-benz[e][1,3]oxazine-2,4-diones. Comparison of the topliss approach with regression analysis

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