Growth Failure Associated with the Use of High Dose Prozac (Fluoxetine Hydrochloride) in a Patient with Type 1 Diabetes Mellitus

doi:10.1515/JPEM.1999.12.3.467

Paper

Growth Failure Associated with the Use of High Dose Prozac (Fluoxetine Hydrochloride) in a Patient with Type 1 Diabetes Mellitus

Published Jan 1, 1999 · R. Navon, G. Frank

Journal of Pediatric Endocrinology and Metabolism

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Abstract

Prozac (fluoxetine hydrochloride) is an antidepressant that has quickly become one of the most prescribed medications in use today. It belongs to the group of serotonin selective reuptake inhibitors (SSRIs), a new class of psychotropic medications with a significantly more tolerable side effect profile than their predecessors. As soon as short term safety and efficacy data became available, fluoxetine became more widespread in its use among the pediatric population. In addition to its use as an antidepressant, fluoxetine is widely used in anxiety disorders'". The most commonly encountered side effects include agitation, gastrointestinal upset, and headache. While other side effects have been encountered, growth failure has not been described. We present a 13 year-old patient who experienced profound growth failure during fluoxetine therapy.

Case Report

Study Snapshot

High doses of fluoxetine (fluoxetine hydrochloride) can cause profound growth failure in patients with type 1 diabetes mellitus.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Growth Failure Associated with the Use of High Dose Prozac (Fluoxetine Hydrochloride) in a Patient with Type 1 Diabetes Mellitus

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