Heartburn in late pregnancy. Manometric studies of esophageal motor function.

doi:10.1172/JCI104335

Paper

Heartburn in late pregnancy. Manometric studies of esophageal motor function.

Published Jun 1, 1961 · R. Nagler, H. Spiro

The Journal of clinical investigation

92

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Abstract

Heartburn is a burning, often hot sensation which may localize in the throat or substernal region. It is especially common during pregnancy. Gastroesophageal reflux and neuromuscular dysfunction of the esophagus have been suggested as underlying pathophysiological mechanisms, but contradictory evidence has prevented a clear definition of the cause of heartburn. A prospective clinical study of 560 pregnant women disclosed that 50 per cent developed heartburn which invariably disappeared after delivery (1). The self-limited character of pregnancy makes it an ideal experimental period during which to study heartburn. Transducer pressure recordings of esophageal motility are well adapted to such a study. This paper reports the results of serial esophageal motility studies in pregnant women with and without heartburn and in a group of asymptomatic normal women of similar age.

Non-RCT

Large Human Trial

Highly Cited

Study Snapshot

Late pregnancy heartburn is common and disappears after delivery, making it an ideal experimental period for studying esophageal motility.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Heartburn in late pregnancy. Manometric studies of esophageal motor function.

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