Paper
Heartburn without oesophagitis: efficacy of omeprazole therapy and features determining therapeutic response.
Published Oct 1, 1997 · T. Lind, T. Havelund, R. Carlsson
Scandinavian journal of gastroenterology
430
Citations
13
Influential Citations
Abstract
BACKGROUND Data are limited on the value of effective antisecretory therapy in the relief of heartburn in patients without oesophagitis. METHODS Patients with heartburn, without endoscopic signs of oesophagitis, were randomized to double-blind treatment with omeprazole, 20 or 10 mg once daily, or placebo, for 4 weeks (n = 509). Pre-treatment oesophageal acid exposure was assessed using 24-h intra-oesophageal pH monitoring. Heartburn was assessed at 2 and 4 weeks. RESULTS At 4 weeks the proportion of patients with complete absence of heartburn was 46% (95% confidence interval, 39-53%) with 20 mg omeprazole, 31% (25-38%) with 10 mg omeprazole, and 13% (7-20%) with placebo. Satisfaction with therapy was reported by 66%, 57%, and 31% of the patients, respectively. CONCLUSION Omeprazole, 20 and 10 mg once daily, provides rapid relief of heartburn in patients without endoscopic oesophagitis.
RCT
Large Human Trial
Highly CitedOmeprazole, 20 and 10 mg once daily, provides rapid relief of heartburn in patients without endoscopic oesophagitis, with satisfaction rates ranging from 66% to 57%.
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