G. Guzzardella, G. Morrone, M. Fini
Jun 1, 2000
Journal of Applied Animal Research
Abstract Guzzardella, G.A., Morrone, G., Fini, M., Rocca, M., Torricelli, P. and Giardino, R. 2000. Histologic evaluation of the repair process of chondral and osteochondral lesions in a rabbit model. J. Appl. Anim. Res, 17: 217–224. Healing of partial and osteochondral surgical cartilaginous lesions to the rabbit femur was studied histologically to determine healing time and quality of the repaired/regenerated tissue, so as to construct an experimental in vivo model for the evaluation of medical and/or surgical therapies, which so far have not ensured complete resolution of the cartilaginous defects. In eighteen New Zealand rabbits, an osteochondral lesion (2.5x2 mm) was drilled in the right femoral medial condyle by lateral cutaneous incision and arthrotomy of each knee was performed, while, a chondral lesion (1.25±0.2 x 0.8±0.2 mm) was created in the left femoral medial condyle of each rabbit. Results showed no healing of the chondral defect and an abnormal bony growth beyond the articular profile with a fibrous coating, even at 12 weeks in osteochondral lesion.