Paper
Manganese homeostasis in the nervous system
Published Aug 1, 2015 · Pan Chen, S. Chakraborty, Somshuvra Mukhopadhyay
Journal of Neurochemistry
234
Citations
9
Influential Citations
Abstract
Manganese (Mn) is an essential heavy metal that is naturally found in the environment. Daily intake through dietary sources provides the necessary amount required for several key physiological processes, including antioxidant defense, energy metabolism, immune function and others. However, overexposure from environmental sources can result in a condition known as manganism that features symptomatology similar to Parkinson's disease (PD). This disorder presents with debilitating motor and cognitive deficits that arise from a neurodegenerative process. In order to maintain a balance between its essentiality and neurotoxicity, several mechanisms exist to properly buffer cellular Mn levels. These include transporters involved in Mn uptake, and newly discovered Mn efflux mechanisms. This review will focus on current studies related to mechanisms underlying Mn import and export, primarily the Mn transporters, and their function and roles in Mn‐induced neurotoxicity.
Literature Review
Highly CitedManganese homeostasis in the nervous system involves transporters, which balance essentiality and neurotoxicity, to prevent conditions like manganism and Parkinson's disease.
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