Imipramine-Flupenthixol Decanoate Interaction
Peter E. Cook, Stanley W. Dermer, Joey Cardamone
Apr 1, 1986
Citations
7
Citations
Journal
The Canadian Journal of Psychiatry
Full text
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Key Takeaway Key Takeaway: Imipramine and flupenthixol decanoate can cause extremely high levels of imipramine and its metabolite desipramine when co-administered in patients with schizophrenia.
Abstract
The authors describe a case in which flupenthixol decanoate and imipramine were co-administered to a patient with schizophrenia, resulting in extremely high levels of imipramine and its metabolite, desipramine. The literature on the co-administration of neuroleptics and antidepressants is reviewed and guidelines for limiting possible iatrogenic effects of the combination are suggested.
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