Follicular helper T (Tfh) cells play a critical role in germinal center formation and B cell activation, both of which are hallmarks of primary Sjögren's syndrome (SS). CCR9‐expressing T helper cells have “Tfh‐like” characteristics and their numbers are increased at mucosa‐associated sites in several inflammatory conditions. Because the characteristics of these cells are unique and evaluation has been limited, this study was undertaken to investigate the local and systemic CCL25/CCR9 axis in patients with primary SS.

Increased CCL25 and CCR9-expressing T helper cells in salivary glands of primary Sjögren's syndrome patients may signal a new pathway for lymphoid neogenesis.

Arthritis & Rheumatology

Increased CCL25 and T Helper Cells Expressing CCR9 in the Salivary Glands of Patients With Primary Sjögren's Syndrome: Potential New Axis in Lymphoid Neogenesis

Increased CCL25 and T Helper Cells Expressing CCR9 in the Salivary Glands of Patients With Primary Sjögren's Syndrome: Potential New Axis in Lymphoid Neogenesis

Key Takeaway: Increased CCL25 and CCR9-expressing T helper cells in salivary glands of primary Sjögren's syndrome patients may signal a new pathway for lymphoid neogenesis.