S. Blokland, M. Hillen, A. Kruize
Oct 1, 2017
Arthritis & Rheumatology
Follicular helper T (Tfh) cells play a critical role in germinal center formation and B cell activation, both of which are hallmarks of primary Sjögren's syndrome (SS). CCR9‐expressing T helper cells have “Tfh‐like” characteristics and their numbers are increased at mucosa‐associated sites in several inflammatory conditions. Because the characteristics of these cells are unique and evaluation has been limited, this study was undertaken to investigate the local and systemic CCL25/CCR9 axis in patients with primary SS.