Increased high-molecular-weight thyrotropin with impaired biologic activity in a euthyroid man.

doi:10.1056/NEJM198101293040506

Paper

Increased high-molecular-weight thyrotropin with impaired biologic activity in a euthyroid man.

Published Jan 29, 1981 · Zamir Chorer, Reuven Sobel, Y. Liel

The New England journal of medicine

42

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Abstract

CIRCULATING high-molecular-weight forms of many polypeptide hormones have been described, but there have been few reports of their occurrence as the predominant forms of glycoprotein hormones.1 2 3 4 5 6 7 8 This paper describes the presence, in a healthy young man, of a high-molecular-weight species of immunoreactive thyrotropin (TSH), which bound normally to the TSH receptor but showed decreased stimulation of the adenylate cyclase of human thyroid membranes. Case Report During studies of 30 to 40 normal medical-student volunteers, a healthy 29-year-old man was discovered to have an elevated serum TSH level in a double-antibody radioimmunoassay. His history was noncontributory, and there was no family . . .

Case Report

Study Snapshot

A high-molecular-weight form of thyrotropin (TSH) in a healthy young man showed decreased stimulation of thyroid membranes, suggesting a possible cause for hypothyroidism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Increased high-molecular-weight thyrotropin with impaired biologic activity in a euthyroid man.

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