This study addressed the problem of how to promote the adherence of endothelial cells (EC) to polyurethane (PU). The influence of basic fibroblast growth factor (bFGF) on the adherence of EC to PU was observed by using the fluorescent method. The results showed that the attachment rates for two bFGF groups(PU precoated with fibronectin and PU precoated with collagen IV) were 71% and 68.5%, which were significantly higher than those (62.5% and 55.25%) for two control groups, respectively. These demonstrate that bFGF can promote EC attachment to PU, and suggest that bFGF can be used as a supplement factor in media for achievement of endothelialization on artificial heart and blood vessels.

bFGF promotes endothelial cell attachment to polyurethane, suggesting its potential use in artificial heart and blood vessel endothelialization media.

[The influence of basic fibroblast growth factor on the adherence of endothelial cell to polyurethane].

Key Takeaway: bFGF promotes endothelial cell attachment to polyurethane, suggesting its potential use in artificial heart and blood vessel endothelialization media.