Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.

doi:10.1016/j.bmcl.2008.07.010

Paper

DOI: 10.1016/j.bmcl.2008.07.010

Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives.

Published Aug 15, 2008 · S. Poulsen, Brendan L Wilkinson, A. Innocenti

Bioorganic & medicinal chemistry letters

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Novel benzenesulfonamides effectively inhibit human mitochondrial carbonic anhydrase isozymes VA and VB, potentially offering potential anti-obesity therapies by reducing lipogenesis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Full text analysis coming soon...

References

DOI: 10.1021/jm701426t

Inhibition of carbonic anhydrases with glycosyltriazole benzene sulfonamides.

Glycoconjugate benzene sulfonamides show potential as potent and selective inhibitors of human carbonic anhydrase, offering potential for future carbonic anhydrase-based therapeutics.

2008·70citations·Brendan L Wilkinson et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.1038/nrd2467

Carbonic anhydrases: novel therapeutic applications for inhibitors and activators

Carbonic anhydrases inhibitors and activators show potential as novel anti-obesity, anticancer, and anti-infective drugs, with potential applications in Alzheimer's disease and other diseases.

2008·2828citations·C. Supuran·Nature Reviews Drug Discovery

Nature Reviews Drug Discovery

DOI: 10.1002/CHIN.200803182

Inhibition of carbonic anhydrase isozymes I, II and IX with benzenesulfonamides containing an organometallic moiety.

These novel organometallic benzenesulfonamides show promising biological activity by inhibiting carbonic anhydrase isozymes I, II, and IX, with ruthenocenyl derivatives showing superior inhibition across all three enzymes.

2007·41citations·A. J. Salmon et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

DOI: 10.1016/J.BMC.2007.04.020

Carbonic anhydrases as targets for medicinal chemistry.

Carbonic anhydrases (CAs) play crucial roles in various physiological and pathological processes, making them attractive targets for designing inhibitors with biomedical applications.

2007·525citations·C. Supuran et al.·Bioorganic & medicinal chemistry

Bioorganic & medicinal chemistry

DOI:

Carbonic Anhydrase: Its Inhibitors and Activators

Carbonic anhydrase inhibitors and activators have potential therapeutic applications in ophthalmology, cancer, and various other fields.

2007·278citations·C. Supuran et al.

Citations

DOI: 10.1113/JP283579

Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease

Carbonic anhydrase VA deficiency is a treatable condition in neonates and young children with hyperammonaemia, and early identification can prevent neurological sequelae.

2022·15citations·Ashok Aspatwar et al.·The Journal of Physiology

The Journal of Physiology

DOI: 10.1002/ardp.202200383

Structure‐guided identification of a selective sulfonamide‐based inhibitor targeting the human carbonic anhydrase VA isoform

VAME-28 is a potent and selective sulfonamide-based inhibitor targeting the mitochondrial isoform hCA VA, offering potential for obesity treatment.

2022·2citations·L. De Luca et al.·Archiv der Pharmazie

Archiv der Pharmazie

DOI: 10.1080/14756366.2022.2121393

Anti-obesity carbonic anhydrase inhibitors: challenges and opportunities

Anti-obesity carbonic anhydrase inhibitors show promise, but detailed antiobesity studies are needed for their potential breakthrough.

2022·36citations·C. Supuran·Journal of Enzyme Inhibition and Medicinal Chemistry

Journal of Enzyme Inhibition and Medicinal Chemistry

DOI: 10.21608/ejchem.2020.33860.2707

Sulfonamides: Synthesis and the recent applications in Medicinal Chemistry

Sulfonamides have diverse pharmacological effects, including oral diuretics, anticancer agents, and antibacterials, with recent launches including apricoxib and pazopanib.

2020·19citations·M. El-Qaliei et al.·The Egyptian Journal of Chemistry

The Egyptian Journal of Chemistry

DOI: 10.1039/d0ra01378a

Benefits and applications of microwave-assisted synthesis of nitrogen containing heterocycles in medicinal chemistry

Microwave-assisted organic synthesis (MAOS) is an efficient and environmentally friendly method for synthesizing nitrogen-containing heterocycles, which are crucial for medicinal applications.

2020·89citations·M. Henary et al.·RSC Advances

RSC Advances

DOI: 10.1016/J.MTCOMM.2018.09.016

Copper(I)-catalyzed azide–alkyne cycloaddition polymerization of N-butyl-N-ethynyl-4-azidobenzenesulfonamide

Copper(I)-catalyzed azide-alkyne cycloaddition polymerizes N-butyl-N-ethynyl-4-azidobenzenesulfonamide (BuEA) to produce nonperiodic sequence-controlled poly

2018·3citations·Tatsuya Harada et al.·Materials Today Communications

Materials Today Communications