Selective inhibition of complex I of the brain electron transport system by tetrahydroisoquinoline.

doi:10.1016/0006-291X(89)90850-4

Paper

DOI: 10.1016/0006-291X(89)90850-4

Selective inhibition of complex I of the brain electron transport system by tetrahydroisoquinoline.

Published Aug 15, 1989 · K. Suzuki, Y. Mizuno, M. Yoshida

Biochemical and biophysical research communications

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Tetrahydroisoquinoline selectively inhibits NADH-ubiquinone reductase in the brain's electron transport system, with similar biochemical properties to the dopaminergic neurotoxin 1-methyl-4-phenylpyridinium ion.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions

Tetrahydroisoquinoline (TIQ) is a potential neurotoxin that causes parkinsonism in marmosets by decreasing dopamine, tyrosine hydroxylase, and biopterin levels in the brain.

1988·208citations·T. Nagatsu et al.·Neuroscience Letters

Neuroscience Letters

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Inhibition of mitochondrial NADH-ubiquinone oxidoreductase activity and ATP synthesis by tetrahydroisoquinoline

Tetrahydroisoquinoline (TIQ) inhibits mitochondrial respiration and ATP synthesis, potentially causing Parkinson's disease.

1988·48citations·Keij Suzuki et al.·Neuroscience Letters

Neuroscience Letters

DOI: 10.1016/0304-3940(87)90366-1

Inhibition of ATP synthesis by 1-methyl-4-phenylpyridinium ion (MPP+) in isolated mitochondria from mouse brains

MPP+ inhibits ATP synthesis in isolated mouse brain mitochondria, potentially contributing to neuronal degeneration in experimental Parkinson's disease.

1987·83citations·Y. Mizuno et al.·Neuroscience Letters

Neuroscience Letters

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Effects of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐Tetrahydropyridine and 1‐Methyl‐4‐Phenylpyridinium Ion on Activities of the Enzymes in the Electron Transport System in Mouse Brain

MPTP and MPP+ both inhibit NADH-ubiquinone oxidoreductase activity in mouse brains, potentially contributing to neuronal degeneration.

1987·228citations·Yoshikuni Mizuno et al.·Journal of Neurochemistry

Journal of Neurochemistry

DOI: 10.1016/S0006-291X(87)80075-X

Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains.

TIQ, an analogue of MPTP, is significantly increased in the parkinsonian brain and may be an endogenous neurotoxin that induces Parkinson's disease.

1987·184citations·T. Niwa et al.·Biochemical and biophysical research communications

Biochemical and biophysical research communications

Citations

DOI: 10.1007/978-1-4612-2000-8

Pharmacology of Endogenous Neurotoxins

Pharmacology of endogenous neurotoxins is a positive activity that will lead to better life concept and a positive hobby to do every time.

2012·14citations·A. Moser

DOI: 10.1002/mds.870090202

Evidence for mitochondrial dysfunction in Parkinson's disease—a critical appraisal

The complex I deficiency in Parkinson's disease provides a biochemical link between the disease and the MPTP toxin model, but the molecular basis and its relevance to the pathogenesis remain unclear.

2004·233citations·A. Schapira·Movement Disorders

Movement Disorders

DOI: 10.1016/S0378-4347(00)00347-9

Development of a method for sample preparation for subsequent identification and measurement of 1,2,3,4-tetrahydroisoquinolines and other potentially neurotoxic compounds by high-performance liquid chromatography with ultraviolet and fluorescence detection in blood plasma of Parkinson's disease pati

This study developed a method for detecting 1,2,3,4-tetrahydroisoquinolines in blood samples from Parkinson's disease patients, using reversed-phase high-performance liquid chromatography with ultraviolet and fluorescence detection.

2000·4citations·P. Pagel et al.·Journal of chromatography. B, Biomedical sciences and applications

Journal of chromatography. B, Biomedical sciences and applications

DOI: 10.1016/S0005-2728(98)00164-9

Mitochondrial involvement in Parkinson's disease, Huntington's disease, hereditary spastic paraplegia and Friedreich's ataxia.

Mitochondrial dysfunction plays a significant role in neurodegeneration, potentially leading to apoptosis and offering potential targets for developing treatments to reverse or prevent neurodegeneration.

1999·316citations·A. Schapira·Biochimica et biophysica acta

Biochimica et biophysica acta

DOI: 10.1016/S0006-2952(98)00142-7

Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease.

High concentrations of and prolonged exposure to isoquinoline derivatives, which are found naturally in the human brain, may cause neurodegeneration and Parkinson's disease in humans.

1998·114citations·K. McNaught et al.·Biochemical pharmacology

Biochemical pharmacology