Paper

Inhibition of microsomal drug metabolic pathways by chloramphenicol.

Published Aug 1, 1962 · Robert L. Dixon, J. R. Fouts

Biochemical pharmacology

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Abstract

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In Vitro Study

Study Snapshot

Chloramphenicol slows hexobarbital biotransformation and prolongs hypnotic action in mice by inhibiting liver microsomal drug metabolism pathways, potentially noncompetitive and irreversible.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Inhibition of microsomal drug metabolic pathways by chloramphenicol.

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