Inhibition of microsomal drug metabolic pathways by chloramphenicol.

doi:10.1016/0006-2952(62)90038-2

Paper

DOI: 10.1016/0006-2952(62)90038-2

Inhibition of microsomal drug metabolic pathways by chloramphenicol.

Published Aug 1, 1962 · Robert L. Dixon, J. R. Fouts

Biochemical pharmacology

Q1 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Chloramphenicol slows hexobarbital biotransformation and prolongs hypnotic action in mice by inhibiting liver microsomal drug metabolism pathways, potentially noncompetitive and irreversible.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Full text analysis coming soon...

References

DOI: 10.1016/0003-9861(56)90366-6

Enzymatic hydroxylation of aromatic compounds.

An enzymatic aromatic hydroxylating system in liver microsomes produces phenolic metabolites from substrates, requiring TPNH and oxygen for activity.

1961·234citations·C. Mitoma et al.·Archives of biochemistry and biophysics

Archives of biochemistry and biophysics

DOI: 10.1016/s0022-3565(25)25935-3

THE EFFECT OF OBSTRUCTIVE JAUNDICE ON DRUG METABOLISM IN RABBITS

Obstructive jaundice in rabbits affects liver microsomal drug metabolism in proportion to the degree of cell damage, with mild damage retaining normal hexobarbital metabolism and severe damage leading to nearly complete loss of drug enzyme activities.

1961·87citations·Edwin F. McLuen et al.·The Journal of Pharmacology and Experimental Therapeutics

The Journal of Pharmacology and Experimental Therapeutics

DOI: 10.1016/s0022-3565(25)11785-0

On the mechanism of drug potentiation by iproniazid (2-isopropyl-1-isonicotinyl hydrazine).

Iproniazid potentiates hexobarbital's hypnotic activity by inhibiting its metabolism, similar to the effects of SKF 525-A and Lilly 18947.

1956·72citations·J. Fouts et al.·The Journal of pharmacology and experimental therapeutics

The Journal of pharmacology and experimental therapeutics

DOI: 10.1016/s0031-6997(25)06996-0

The effects of drugs on enzyme systems.

Drug-enzyme interactions are complex and diverse, and rational drug development remains a challenge in the face of this complexity.

1956·57citations·F. E. Hunter et al.·Pharmacological reviews

Pharmacological reviews

DOI: 10.1016/s0022-3565(25)11590-5

Inhibition of drug metabolic pathways by the potentiating agent, 2, 4-dichloro-6-phenyl-phenoxyethyl diethylamine.

Lilly 18947 prolongs hypnotic activity of hexobarbital by inhibiting its biotransformation, potentially acting by a similar mechanism to the SKF compounds.

1955·51citations·J. Fouts et al.·The Journal of pharmacology and experimental therapeutics

The Journal of pharmacology and experimental therapeutics

Citations

DOI: 10.1111/J.1439-0442.1977.TB01749.X

Chloramphenicol-Wirkungen auf Enzymsysteme innerhalb des Arzneimittelabbaus

Chloramphenicol, a broad-spectrum antibiotic, can prolong narcosis duration by enzymatic breakdown, slow down local anesthetic degradation, and reduce the toxicity of insecticide parathion (E 605).

2010·1citation·H. Hapke et al.·Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine

Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine

DOI: 10.1111/J.1439-0442.1983.TB00685.X

Beitrag zur Pharmakokinetik von Chloramphenicol und Tylosin in Kombinationspräparaten

Chloramphenicol significantly slows down tylosin elimination in rats and 3-day-old calves, with a significant dependence on animal maturity.

2010·0citations·M. Kietzmann et al.·Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine

Journal of Veterinary Medicine Series A-physiology Pathology Clinical Medicine

DOI:

The effect of chloramphenicol on hepatic biotransformation enzyme activity and on the duration of pentobarbital or ketamine/xylazine anesthesia in guinea pigs (Cavia porcellus).

Chloramphenicol decreases liver enzyme activity but does not prolong anesthesia duration in guinea pigs, unlike dogs, cats, rats, and mice.

2009·2citations·A. P. Crnić et al.·Veterinarski Arhiv

Veterinarski Arhiv

DOI: 10.1111/J.1600-0773.1981.TB00903.X

Methyl mercury decomposition in mice treated with antibiotics.

Antibiotics reduce intestinal microorganisms, leading to reduced methyl mercury decomposition and faecal excretion in mice.

2009·29citations·Y. Seko et al.·Acta pharmacologica et toxicologica

Acta pharmacologica et toxicologica

DOI: 10.1016/S0195-5616(93)50311-X

Hepatotoxicity associated with pharmacologic agents in dogs and cats.

Pharmacologic agents can cause hepatotoxicity in dogs and cats, with recent examples including diethylcarbamazine/oxibendazole, phenobarbital, and trirnethoprirnlsulfadiazine.

1993·34citations·Susan E. Bunch·The Veterinary clinics of North America. Small animal practice

The Veterinary clinics of North America. Small animal practice

DOI: 10.1016/0041-008X(90)90141-G

The role of epoxidation in 4-vinylcyclohexene-induced ovarian toxicity.

VCH-induced ovarian tumors in mice involve metabolism to epoxides and oocyte destruction, while rats may be resistant due to insufficient conversion to epoxides.

1990·118citations·Bill J. Smith et al.·Toxicology and applied pharmacology

Toxicology and applied pharmacology

DOI: 10.1016/0006-2952(89)90068-3

Cocaine-induced changes in perfusion pressure and bile flow in perfused rat livers.

Cocaine increases perfusion pressure in the liver, decreases bile flow, and reduces oxygen uptake, without relying on alpha-receptor activation or prostaglandins.

1989·6citations·C. Garhart et al.·Biochemical pharmacology

Biochemical pharmacology

DOI: 10.1016/0147-6513(86)90017-5

Effects of phenobarbital, chlordane, and oxytetracycline on DDT excretion in rats.

Phenobarbital and chlordane increase biliary excretion of DDT in rats, while oxytetracycline increases biliary flow but does not affect DDT excretion.

1986·1citation·F. R. Puga et al.·Ecotoxicology and environmental safety

Ecotoxicology and environmental safety