L-Azetidine-2-carboxylic acid (AZC), an analogue of proline, has been shown to partially ameliorate hepatic cirrhosis induced in rats by CCl(4). AZC caused a diminution in formation of collagen in the liver accompanied by a relative decrease in the pool of free proline. The synthesis of noncollagenous proteins in the livers of treated rats did not appear to be affected.

L-Azetidine-2-carboxylic acid (AZC) partially ameliorates liver fibrosis in rats treated with carbon tetrachloride, reducing collagen formation and free proline levels without affecting noncollagenous protein synthesis.

Paper

Inhibition of liver fibrosis by 1-azetidine-2-carboxylic acid in rats treated with carbon tetrachloride.

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