Insulin resistance: Impact on therapeutic developments in diabetes

doi:10.1177/1479164119827570

Paper

Insulin resistance: Impact on therapeutic developments in diabetes

Published Mar 1, 2019 · C. Bailey

Diabetes & Vascular Disease Research

Q2 SJR score

6

Citations

0

Influential Citations

PDF

Semantic Scholar

Abstract

Insulin resistance has a broad pathogenic impact affecting metabolic, cardio-renal and other disease areas. Extensive studies to dissect the mechanisms of insulin resistance have provided valuable insights to shape current clinical awareness and advance therapeutic practice. However, the development of direct interventions against insulin resistance has been hindered by its complex and highly variable presentations, especially in type 2 diabetes. Among glucose-lowering agents, metformin and thiazolidinediones provide cellular actions that counter some effects of insulin resistance: reduced glucotoxicity and weight-lowering with antidiabetic therapies also improve insulin action, except that endogenously- or exogenously-created hyperinsulinaemia may partially compromise these benefits. Increasing awareness of the pervasiveness and damaging ramifications of insulin resistance heightens the need for more specifically targeted and more effective therapies.

Rigorous Journal

Study Snapshot

Key takeawayInsulin resistance has a complex and variable presentation, hindering the development of targeted and effective therapies for type 2 diabetes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Insulin resistance: Impact on therapeutic developments in diabetes

References

Citations