Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach.

doi:10.1016/j.bmcl.2016.02.081

Paper

Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach.

Published Apr 15, 2016 · J. Kajanus, I. Jacobson, A. Åstrand

Bioorganic & medicinal chemistry letters

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14

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Abstract

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Study Snapshot

Isoindolinone compounds show good in vitro potency on the Kv1.5 ion channel, with metabolically stable compounds and low microsomal intrinsic clearance achieved through a multicomponent reaction approach.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach.

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