Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease

doi:10.1016/j.brainres.2009.06.060

Paper

Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease

Published Aug 25, 2009 · Bao-hua Cheng, Xinxin Yang, Liangxiang An

Brain Research

Q2 SJR score

105

Citations

5

Influential Citations

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

A high-fat ketogenic diet protects dopaminergic neurons from 6-OHDA neurotoxicity by up-regulating glutathione levels in a rat model of Parkinson's disease.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease

References

Oxidative Stress in Parkinson's Disease

Oxidative stress contributes to Parkinson's disease by directly killing some dopaminergic neurons and indirectly activating intracellular cell death pathways, suggesting a multifactorial pathogenic cascade.

The ketogenic diet increases mitochondrial glutathione levels

The ketogenic diet increases mitochondrial glutathione levels, enhances mitochondrial antioxidant status, and protects mitochondrial DNA from oxidant-induced damage.

6-Hydroxydopamine induces mitochondrial ERK activation.

Metalloporphyrin antioxidants can protect neurons from 6-hydroxydopamine toxicity when added within 1 hour, but their effectiveness decreases after 15 minutes.

Role of Cdk5-Mediated Phosphorylation of Prx2 in MPTP Toxicity and Parkinson's Disease

Cdk5-mediated phosphorylation of Prx2 plays a crucial role in mitochondrial toxin-induced dopaminergic death and Parkinson's disease, with increased Prx2 phosphorylation also occurring in postmortem nigral neurons from Parkinson's disease patients.

Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage through inhibition of microglia activation and proinflammatory factors generation

Biochanin A protects dopaminergic neurons from lipopolysaccharide-induced damage by inhibiting microglia activation and proinflammatory factors generation.

Citations