Paper
Kinetics of fluphenazine after fluphenazine dihydrochloride, enanthate and decanoate administration to man.
Published Apr 1, 1979 · S. Curry, R. Whelpton, P. De Schepper
British journal of clinical pharmacology
71
Citations
2
Influential Citations
Abstract
1 Fluphenazine (1,2-ethanol 14C) was administered to seven human subjects as the dihydrochloride and as the enanthate and decanoate esters. 2 The subjects had previously been treated with fluphenazine injections for at least 6 months. 3 Fluphenazine was separated from its radioactive metabolites by selective solvent extraction. Plasma concentrations were measured for up to 21 days after dosing. 4 The preparations showed differences in peak concentrations, times of the peaks and half-times of the elimination phase. The longest half-times occurred with the decanoate and the shortest with the dihydrochloride. 5 It is postulated that the differences in kinetics relate principally to the release of the compound from the site of injection. 6 There was no evidence for presence of the esters in plasma, urine or faeces.
Non-RCT
Highly CitedFluphenazine administration in humans shows differences in peak concentrations, times of peaks, and elimination half-times, with the dihydrochloride showing the shortest half-time and enanthate and decanoate esters having longer half-times.
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