Lack of genotoxic activity of 2-(2',4'-diaminophenoxy)ethanol in Escherichia coli strains WP2, WP2uvrA and WP2uvrA/recA.

doi:10.1016/0165-1218(82)90092-1

Paper

Lack of genotoxic activity of 2-(2',4'-diaminophenoxy)ethanol in Escherichia coli strains WP2, WP2uvrA and WP2uvrA/recA.

Published Dec 1, 1982 · R. M. Hastwell, D. Mcgregor

Mutation research

UNKNOWN SJR score

3

Citations

0

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

The new hair-dyeing ingredient, 2-(2',4'-diaminophenoxy)ethanol, shows no genotoxic potential in Escherichia coli strains WP2, WP2uvrA, and WP2uvrA/recA.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Lack of genotoxic activity of 2-(2',4'-diaminophenoxy)ethanol in Escherichia coli strains WP2, WP2uvrA and WP2uvrA/recA.

References

Mutagen testing using TRP+ reversion in Escherichia coli.

TRP+ reversion in Escherichia coli strains can effectively detect agents causing DNA damage, with four different test methods available for detecting mutations and DNA damage.

Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.

The Salmonella/mammalian-microsome mutagenicity test is a reliable and cost-effective method for detecting carcinogens and mutagens.

Genotoxic activity in microorganisms of tetryl, 1,3-dinitrobenzene and 1,3,5-trinitrobenzene.

Tetryl, 1,3-dinitrobenzene, and 1,3,5-trinitrobenzene show genotoxic potential in microorganisms, with tetryl showing strong mutagenic activity and 1,3-dinitrobenzene showing moderate mutagenic activity.

Citations

Final Report on the Safety Assessment of 2,4-Diaminophenoxyethanol Dihydrochloride

2,4-DAPE is safe as a cosmetic ingredient in current practices, with no teratogenic effects, no mutagenic activity, and no carcinogenic effects observed.

Hair Dye Toxicology

Hair dye ingredients may interact with DNA, causing mutations or cancer, but the significant risk to users remains unclear.

The hair-dye reagent 2-(2',4'-diaminophenoxy)ethanol is mutagenic to Salmonella typhimurium.

2,4-DAPE, a new hair-dye ingredient, is mutagenic to Salmonella typhimurium, contradicting previous claims that it is inactive in short-term tests.