Lack of initiating capacity of the genotoxic air pollutant 2-nitrofluorene in the mouse skin two-stage carcinogenesis system.

doi:10.1093/CARCIN/14.8.1723

Paper

Lack of initiating capacity of the genotoxic air pollutant 2-nitrofluorene in the mouse skin two-stage carcinogenesis system.

Published Aug 1, 1993 · L. Möller, M. Zeisig, R. Toftgård

Carcinogenesis

Q1 SJR score

6

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0

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Abstract

2-Nitrofluorene (NF) is a potent genotoxic substance found in environments where incomplete combustion takes place. NF is a mutagen and a carcinogen in animal models. NF or 7,12-dimethylbenz[a]anthracene (DMBA) was administered once topically to female SENCAR mice followed by promotion by 12-O-tetradecanoylphorbol-13-acetate (TPA) in two different studies. TPA (2-5 micrograms) was administered twice a week for 13 or 19 weeks after initiation of DMBA (5-10 micrograms) or NF (50-1500 micrograms). DMBA administration (positive control) resulted in the formation of many papillomas, which were seen from week 8-9 after initiation. The negative controls administered acetone only were free of tumours. NF administration did not result in papilloma formation, even at high initiating doses of NF combined with a dose of TPA causing a systemic toxic effect in terms of a significant reduced body weight. The mechanism behind the absence of papilloma formation after administration of genotoxic and carcinogenic NF remains to be investigated.

Non-RCT

Animal Study

Study Snapshot

2-Nitrofluorene does not initiate skin cancer in mice, even at high doses, suggesting its lack of initiating capacity in the mouse skin two-stage carcinogenesis system.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Lack of initiating capacity of the genotoxic air pollutant 2-nitrofluorene in the mouse skin two-stage carcinogenesis system.

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