Fomitopsis officinalis is a medicinal fungus, known as ‘Agarikon’, and is used traditionally in the treatment of asthma and rheumatism in Mongolia. The investigation of the chemical constituents of F. officinalis led to the isolation of 4 new lanostane triterpenoids together with 4 known triterpenoids. Inhibitory activity against Trypanosoma congolense, which causes fatal diseases in animals including livestock, was estimated for the isolated compounds. Compounds 2–5 and 8 exhibited moderate inhibition activities with IC50 values ranging from 7.0−27.1 µM.

Lanostane triterpenoids from Fomitopsis officinalis show moderate inhibitory activity against Trypanosoma congolense, potentially benefiting livestock health.

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Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity

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