Mechanism of neurotoxic action of β,β′-iminodipropionitrile (IDPN): N-hydroxylation enhances neurotoxic potency

doi:10.1016/0006-8993(87)91527-7

Paper

DOI: 10.1016/0006-8993(87)91527-7

Mechanism of neurotoxic action of β,β′-iminodipropionitrile (IDPN): N-hydroxylation enhances neurotoxic potency

Published Dec 22, 1987 · A. Morandi, P. Gambetti, P. K. Arora

Brain Research

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

The N-hydroxy analog of,′-iminodipropionitrile (HOIDPN) is approximately 8 times more potent than the parent substance, suggesting a flavin monooxygenase-mediated N-oxygenation pathway.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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This study developed a high-throughput, metabolism-mediated neurotoxicity testing system that incorporates liver biotransformation and can predict the susceptibility of compounds and their metabolites to induce neurotoxicity.

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Vestibulotoxic properties of potential metabolites of allylnitrile.

3,4-epoxybutyronitrile is the active metabolite of allylnitrile for vestibular toxicity, with 3,4-dihydroxybutyronitrile and 4-hydroxybut-2-enenitrile showing no such toxicity.

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