Molecular mechanism underlying antileishmanial effect of oxabicyclo[3.3.1]nonanones: inhibition of key redox enzymes of the pathogen.

doi:10.1016/j.ejpb.2013.08.014

Paper

Molecular mechanism underlying antileishmanial effect of oxabicyclo[3.3.1]nonanones: inhibition of key redox enzymes of the pathogen.

Published Nov 1, 2013 · Prakash Saudagar, Pipas Saha, A. Saikia

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

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54

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4

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Abstract

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In Vitro Study

Study Snapshot

Oxabicyclo[3.3.1]nonanones inhibit key Leishmania redox enzymes, leading to increased reactive oxygen species, mitochondrial damage, and apoptosis, offering a potential new antileishmanial drug target.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Molecular mechanism underlying antileishmanial effect of oxabicyclo[3.3.1]nonanones: inhibition of key redox enzymes of the pathogen.

References

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