Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro-indazole

doi:10.1016/0028-3908(94)90024-8

Paper

DOI: 10.1016/0028-3908(94)90024-8

Molecular mechanisms of inhibition of porcine brain nitric oxide synthase by the antinociceptive drug 7-nitro-indazole

Published Nov 1, 1994 · Bernd Mayer, Peter Klatt, E. Werner

Neuropharmacology

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126

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Highly Cited

Study Snapshot

7-nitro-indazole and imidazole both bind to nitric oxide synthase in an l-arginine-competitive manner, with 7-NI also affecting the pteridine site of the enzyme.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1042/BJ3040189

Synthesis and characterization of 3H-labelled tetrahydrobiopterin.

[3'-3H]-5,6,7,8-tetrahydrobiopterin is a radiochemically pure, radioactive compound suitable for studying tetrahydrobiopterin binding to nitric-oxide synthase.

1994·17citations·E. Werner et al.·The Biochemical journal

The Biochemical journal

DOI: 10.1042/BJ3010313

Uptake of nitric oxide synthase inhibitors by macrophage RAW 264.7 cells.

Macrophages uptake of nitric oxide synthase inhibitors NG-methyl-L-arginine (L-NMA) and NG-nitro-L-arginine (L-NNA) is mediated by two different mechanisms, with cytokine activation enhancing L-

1994·43citations·K. Schmidt et al.·The Biochemical journal

The Biochemical journal

DOI: 10.1016/s0021-9258(17)36726-1

The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.

Brain nitric oxide synthase exhibits a highly specific binding site for (6R)-5,6,7,8-tetrahydro-L-biopterin, which interacts with the substrate domain and may be proximal to the prosthetic heme group.

1994·205citations·P. Klatt et al.·The Journal of biological chemistry

The Journal of biological chemistry

DOI: 10.1038/368635A0

Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation

Guanylyl cyclase and cGMP-dependent protein kinase contribute to long-term potentiation in the hippocampus, possibly as activity-dependent presynaptic effectors of retrograde messengers.

1994·445citations·M. Zhuo et al.·Nature

Nature

DOI: 10.1016/s0021-9258(17)42080-1

Inhibitors of brain nitric oxide synthase. Binding kinetics, metabolism, and enzyme inactivation.

NG-methyl-L-arginine shows the same affinity for brain nitric oxide synthase as NG-nitro-L-arginine, but after prolonged incubation, it becomes a substrate, slowly converting into NO and L-citrulline.

1994·154citations·Peter Klatt et al.·The Journal of biological chemistry

The Journal of biological chemistry

Citations

DOI: 10.1016/j.jinorgbio.2020.111298

Heat shock protein 90α increases superoxide generation from neuronal nitric oxide synthases.

Heat shock protein 90 significantly increases superoxide generation from neuronal nitric oxide synthases, with distinct effects on nNOS and nNOS proteins.

2020·3citations·Huayu Zheng et al.·Journal of inorganic biochemistry

Journal of inorganic biochemistry

DOI: 10.2174/1570180816666190222154457

Nitric Oxide Synthases and Their Inhibitors: A Review

Nitric oxide synthases (NOS) play a crucial role in regulating various systems in mammals, and computational techniques can help develop inhibitors for their various isoforms.

2020·9citations·Anshika Mittal and Rita Kakkar·Letters in Drug Design & Discovery

Letters in Drug Design & Discovery

DOI: 10.1016/j.niox.2019.04.007

Site and mechanism of uncoupling of nitric-oxide synthase: Uncoupling by monomerization and other misconceptions.

Uncoupling of nitric oxide synthase occurs exclusively at the heme, with minimal contribution from flavins and no role for NOS monomerization.

2019·37citations·Verena Gebhart et al.·Nitric oxide : biology and chemistry

Nitric oxide : biology and chemistry

DOI: 10.1042/BCJ20160999

Superoxide generation from nNOS splice variants and its potential involvement in redox signal regulation.

The nNOS- variant generates 44% of the superoxide produced by nNOS-, potentially playing a role in redox signaling and neuronal systems.

2017·13citations·H. Ihara et al.·The Biochemical journal

The Biochemical journal

DOI: 10.1161/HYPERTENSIONAHA.115.07032

Inhibition of Nitric Oxide Synthase 1 Induces Salt-Sensitive Hypertension in Nitric Oxide Synthase 1&agr; Knockout and Wild-Type Mice

Inhibiting NOS1&bgr; in NOS1&agr;KO mice induces salt-sensitive hypertension, while NOS1&agr;KO mice show no such hypertension.

2016·20citations·Ximing Wang et al.·Hypertension

Hypertension