Mechanisms of prednisolone action in erythropoiesis.

doi:10.1210/ENDO-81-2-363

Paper

Mechanisms of prednisolone action in erythropoiesis.

Published Aug 1, 1967 · A. S. Gordon, E. Mirand, E. Zanjani

Endocrinology

Q1 SJR score

20

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0

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Abstract

Daily administration for 4 days of doses of methyl prednisolone acetate (MPA) ranging from 0.5 to 4.0 mg depressed erythropoiesis in normal mice; this effect was partially overcome by administration of erythropoiesisstimulating factor (ESF). The mechanism of this inhibitory action of MPA on erythropoiesis involves: 1) a diminution in the numbers and/or the response of hemic stem cells to ESF as seen in both normal and plethoric mice, and 2) a depression of ESF production, noted with the higher dose level (4 mg) in mice subjected to hypoxia. The ability of MPA to counteract the erythropoiesis-stimulating effect of hypoxia was not attributable to the presence of erythropoiesisinhibiting factors in the plasma. This was shown from the inability of plasma secured from MPAtreated mice to depress erythropoiesis in normal mice or to inhibit the action of exogenous ESF in plethoric mice. (Endocrinology 81: 363, 1967)

Non-RCT

Animal Study

Study Snapshot

Prednisolone reduces erythropoiesis in normal mice by decreasing hemic stem cell response to ESF and reducing ESF production, but its ability to counteract hypoxia-stimulating effects is not due to presence of erythropoiesis-inhibiting factors in plasma.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Mechanisms of prednisolone action in erythropoiesis.

References

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