Paper
Mechanisms of thermal responses to 2,4-dinitrophenol.
Published 1963 · I. Shemano, M. Nickerson
The Journal of pharmacology and experimental therapeutics
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Abstract
2,4-Dinitrophenol (DNP) produced a consistent hyperthermia in lightly restrained rats at ambient temperatures above 20 to 22°C, and a hypothermia at lower ambient temperatures. DNP failed to affect body temperature in curarized rats at a low ambient temperature. DNP produced a smaller increase in oxygen consumption of lightly restrained rats at lower ambient temperatures. In contrast to its effects in rats, DNP in doses of 3.0 and 20 mg/kg did not affect the body temperature of lightly restrained dogs at low ambient temperatures (10 and 4°C). Visible shivering was not noticeably influenced by the dose of 3.0 mg/kg but was greatly diminished by 20 mg/kg. A relative hyperthermia was produced in dogs completely paralyzed with a neuromuscular blocking agent at all ambient temperatures studied (5 to 20°C). The hyperthermia was due to increased heat production which was not significantly different at different ambient temperatures. Intracarotid infusion of a small dose of DNP in "curarized" dogs over a 10-minute period produced a much smaller increase in oxygen consumption than did intravenous infusion of the same dose. These results indicate that the hypothermic effect of DNP probably is due to both a centrally-mediated inhibition of the skeletal muscle thermogenic response to cold and to a reduced metabolic effect of DNP at low ambient temperatures. The hyperthermic effect of DNP, on the other hand, probably can be attributed entirely to a peripherally-mediated thermogenic action.
Non-RCT
Animal Study2,4-dinitrophenol causes hypothermia in rats at low temperatures due to central inhibition of skeletal muscle thermogenic response and reduced metabolic effect, while its hyperthermic effect is mainly due to peripheral thermogenic action.
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