Melasma pathogenesis: a review of the latest research, pathological findings, and investigational therapies.

doi:10.5070/d32510045810

Paper

Melasma pathogenesis: a review of the latest research, pathological findings, and investigational therapies.

Published Oct 15, 2019 · Susruthi Rajanala, M. Maymone, N. Vashi

Dermatology online journal

Q3 SJR score

64

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1

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Abstract

Melasma is an acquired hyperpigmentation disorder most commonly affecting females with darker skin types. It is triggered by several factors including sun exposure, genetic influences, and female sex hormones. The pathology of melasma extends beyond melanocytes and recent literature points to interactions between keratinocytes, mast cells, gene regulation abnormalities, neovascularization, and disruption of basement membrane. This complex pathogenesis makes melasma difficult to target and likely to recur post treatment. A better understanding of the latest pathological findings is key to developing novel and successful treatment options. This review aims to provide a summary of the more novel pathological findings and latest investigational therapies.

Literature Review

Study Snapshot

Key takeawayMelasma's complex pathogenesis requires novel treatment options, with a focus on understanding interactions between keratinocytes, mast cells, gene regulation abnormalities, neovascularization, and basement membrane disruption.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Melasma pathogenesis: a review of the latest research, pathological findings, and investigational therapies.

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