Paper
Metabolism of 6,7-dimethoxy 4-(p-chlorobenzyl)-isoquinoline. I. Single-dose pharmacokinetics in the rat and mouse.
Published Jul 1, 1985 · A. Servin, C. Jacquot, J. Lussiana
Xenobiotica; the fate of foreign compounds in biological systems
UNKNOWN SJR score
6
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0
Influential Citations
Abstract
The pharmacokinetics of 6,7-dimethoxy 4-(p-chlorobenzyl) isoquinoline (PV 2) in mouse and rat show that it is 52% absorbed after oral administration and undergoes a marked hepatic first-pass effect (83%). Tissue distribution shows an affinity for the aorta, cardiac tissues and cerebral blood vessels. It is excreted in the urine (20% dose) and faeces (70%); biliary excretion is high (80% dose). It is metabolized mainly by O-demethylation to 6- and 7-desmethyl-PV 2 and 6,7-didesmethyl-PV 2, as well as to six other non-identified metabolites.
Non-RCT
Animal StudyStudy Snapshot
6,7-dimethoxy 4-(p-chlorobenzyl)-isoquinoline (PV2) is 52% absorbed after oral administration, undergoes a marked hepatic first-pass effect, and is mainly metabolized by O-demethylation to 6- and 7-des
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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Metabolism of 6,7-dimethoxy 4-(4'-chlorobenzyl)isoquinoline. II. Role of liver catechol O-methyltransferase and glutathione.
Glutathione conjugation plays a crucial role in the detoxication of 6,7-dimethoxy-4(4'-chlorobenzyl)isoquinoline and its metabolites in vivo.
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