A method for evaluating therapy for hay fever
Published Jul 1, 1983 · M. D'souza, M. Emanuel, J. Gregg
Clinical & Experimental Allergy
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Abstract
This study was undertaken in order to develop a method for comparing the value of different forms of treatment for hay fever. A cross‐over trial was carried out in sixty‐one patients, comparing four treatments: topical corticosteroids, topical cromoglycales, placebo tablets and oxatomide (a new oral treatment with antihistamine and cromoglycate‐like properties). Three methods were used to compare these treatments: (1) post‐treatment symptom questionnaires; (2) daily analogue line scores of symptoms; and (3) nasal FEV1. Of these, daily analogue line diary scores, with an analysis which took into account variation in pollen count, proved to be the most sensitive.