Methoxycarbonylmethylation of Aldehydes via Siloxycyclopropanes: Methyl 3,3‐Dimethyl‐4‐Oxobutanoate

doi:10.1002/0471264180.OS071.24

Paper

Methoxycarbonylmethylation of Aldehydes via Siloxycyclopropanes: Methyl 3,3‐Dimethyl‐4‐Oxobutanoate

Published Apr 28, 2003 · H. Reissig, I. Reichelt, T. Kunz

Organic Syntheses

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Abstract

Methoxycarbonylmethylation of aldehydes via siloxycyclopropanes: methyl 3,3-dimethyl-4-oxobutanoate intermediate: 2-methyl-1-(trimethylsiloxy)propene intermediate: methyl 2,2-dimethyl-3-(trimethylsiloxy)-1-cyclopropanecarboxylate reactant: 24.0 g (240 mmol) of methyl diazoacetate product: methyl 3,3-dimethyl-4-oxobutanoate Keywords: annulation, carbocyclic-[3]; cyclization, free radical-carbenoid/nitrenoid; cyclopropanation; deprotection, oxygen; metal-catalyzed reactions, copper; rearrangements; ring opening reactions; silylation; chlorotrimethylsilane, drying of; N,N-dimethylformamide; ethyl acetate; sodium iodide; triethylamine; triethylamine hydrofluoride, preparation; diazo compounds; N,N-dimethylformamide, cancer suspect agent; methyl diazoacetate, potential explosive; pyrolysis apparatus, flash vacuum pyrolysis

Study Snapshot

Methoxycarbonylmethylation of aldehydes via siloxycyclopropanes produces methyl 3,3-dimethyl-4-oxobutanoate, a potential explosive and cancer suspect agent.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Methoxycarbonylmethylation of Aldehydes via Siloxycyclopropanes: Methyl 3,3‐Dimethyl‐4‐Oxobutanoate

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