Methyl-alpha-D-mannopyranoside, mannooligosaccharides and yeast mannans inhibit development of rat adjuvant arthritis.

Paper

Methyl-alpha-D-mannopyranoside, mannooligosaccharides and yeast mannans inhibit development of rat adjuvant arthritis.

Published Apr 1, 1993 · A. Prokopova, V. Kéry, M. Stančíková

The Journal of rheumatology

Q1 SJR score

9

Citations

0

Influential Citations

Semantic Scholar

Abstract

Methyl-alpha-D-mannopyranoside, mannooligosaccharides obtained by acetolysis of yeast mannan, and pure mannans isolated from the cell walls of pathogenic (Candida albicans) and nonpathogenic (Saccharomyces cerevisiae) yeasts were used for treatment of rat adjuvant arthritis. The arthritis was induced by the application of Freund's complete adjuvant into the tail region of rats. The mannose substances were injected into the arthritic rats intraperitonealy at different time intervals. Levels of serum albumin, changes in hindpaws swelling and radiographs were measured in infected rats as variables of the inflammation and destructive arthritic changes. While mannan from C. albicans inhibited both the inflammation and destructive arthritic changes, mannan from S. cerevisiae showed less effect. However, acetolysate of S. cerevisiae mannan as well as simple methyl-alpha-D-mannopyranoside inhibited both inflammation and destructive arthritic changes to a similar degree as mannan isolated from C. albicans. The effect, which is not dose dependent indicates its possible immunoregulatory mechanism. This is the first time a therapeutic effect of simple carbohydrates on rat adjuvant arthritis has been described.

Non-RCT

Animal Study

Study Snapshot

Simple carbohydrates, such as methyl-alpha-D-mannopyranoside and mannooligosaccharides, effectively inhibit the development of rat adjuvant arthritis, suggesting a potential immunoregulatory mechanism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Methyl-alpha-D-mannopyranoside, mannooligosaccharides and yeast mannans inhibit development of rat adjuvant arthritis.

References

Citations

The Immunomodulatory Effect of Trichophyton Rubrum Exoantigens in the Treatment of Experimental Septic Arthritis

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Treatment with Selemax®, a selenium-enriched yeast, ameliorates experimental arthritis in rats and mice.

Selemax® treatment reduces inflammation and improves function in arthritis models, suggesting it should be evaluated in patients with rheumatoid arthritis.

Modern Pharmacological Approaches to Therapies: Substances Tested in Animal Models of Rheumatoid Arthritis

Combinatory therapy using immunomodulators and compounds affecting reduction/oxidation homeostasis may improve rheumatoid arthritis treatment efficacy without increasing toxicity.

Study of new ways of supplementary and combinatory therapy of rheumatoid arthritis with immunomodulators. Glucomannan and Imunoglukán® in adjuvant arthritis

Imunoglukán® shows potential as a combination therapy for rheumatoid arthritis, with beneficial effects on paw volume and cytokine levels, making it a potential candidate for combination therapy.

Antioxidant properties of yeast (1→3)-β-d-glucan studied by electron paramagnetic resonance spectroscopy and its activity in the adjuvant arthritis

Yeast (1-3)--d-glucan (CMG) shows potential antioxidant properties and shows a decline in plasmatic carbonyls in rats with experimentally induced adjuvant arthritis, suggesting potential applications in arthritis treatment.