Among the hematologic complications associated to cancer, microangiopathic hemolytic anemia and leukoerythroblastosis are rarely reported together. We present the case of a patient with gastric adenocarcinoma that presented clinically with microangiopathic hemolytic anemia and leukoerythroblastosis in peripheral blood as a result of metastatic invasion of the bone marrow. We discuss the probable etiopathogenic relation of these two entities with cancer, the therapeutic possibilities and the primary role of bone marrow biopsy and examination of the peripheral blood smear as more reliable diagnostic methods.

Microangiopathic hemolytic anemia and leukoerythroblastosis are rare complications in gastric adenocarcinoma patients, but may be related to metastatic bone marrow invasion, and bone marrow biopsy and peripheral blood smear are reliable diagnostic methods.

[Microangiopathic hemolytic anemia and leukoerythroblastosis as the presenting form of a gastric adenocarcinoma].

Key Takeaway: Microangiopathic hemolytic anemia and leukoerythroblastosis are rare complications in gastric adenocarcinoma patients, but may be related to metastatic bone marrow invasion, and bone marrow biopsy and peripheral blood smear are reliable diagnostic methods.