New Microglia on the Block.

doi:10.1016/j.cmet.2020.03.015

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New Microglia on the Block.

E. S. Jung, I. Mook‐Jung

Apr 1, 2020

Citations

Journal

Cell metabolism

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Key Takeaway

Key Takeaway: LDAM microglia contribute to neuronal inflammation and age-related neurodegeneration, with potential implications for understanding neurodegeneration and aging.

Abstract

Microglia exhibit differing functions and phenotypes depending on life stage and the context of health or disease. Recently, in Nature Neuroscience, Marschallinger et al. (2020) described a new state of microglia, namely "lipid-droplet-accumulating microglia" (LDAM), that contributes to neuronal inflammation and age-related neurodegeneration.

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