Paper
Middle Ear Infections in Pediatric Patients: Treatment with Amoxicillin
Published Jun 1, 1974 · G. Aronovitz
The Journal of Infectious Diseases
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Abstract
Amoxicillin, a new semisynthetic penicillin, was compared with ampicillin in the treatment of otitis media. Pediatric patients from a private practice underwent aspiration of the middle ear for culture. Sixty-seven patients were treated with either amoxicillin three times a day or with ampicillin four times a day. The dose of ampicillin was approximately twice the dose of amoxicillin. Only one of 48 amoxicillin-treated and one of 19 ampicillin-treated patients failed to respond. Amoxicillin was well tolerated, with a single patient developing eosinophilia. None of the patients treated with amoxicillin developed a rash, while one treated with ampicillin did. Amoxicillin administered three times a day is an effective program for the treatment of bacterial otitis media. Middle ear infections have continued to be a problem of major importance to the practicing pediatrician; the development of many antibiotics effective against the three causative organisms (Haemophilus influenzae, Diplococcus pneumoniae, and Streptococcus pyogenes) has not lessened the incidence or significance of such infections. Amoxicillin, a new semisynthetic penicillin
Non-RCTAmoxicillin administered three times a day effectively treats bacterial middle ear infections in pediatric patients, with well-tolerated and well-tolerated side effects.
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