Shin Hashizume, M. Nakano, Kenta Kubota
Feb 17, 2021
Journal name not available for this finding
Although mindfulness-based stress reduction (MBSR) improves cognitive function, the mechanism is not clear. In this study, people aged 65 years and older were recruited from elderly communities in Chitose City, Japan, and assigned to the non-MBSR group or MBSR group. In the MBSR group, the program was performed three times a week for 4 weeks. After the intervention, the score of Japanese version of the Montreal Cognitive Assessment (MoCA-J) as well as the expression of microRNA (miR)-29c in neuron-derived exosomes (NDEs) in blood was significantly increased in the MBSR group, compared to the non-MBSR group. Analysis of miR-29c target genes showed that the expression of DNA methyltransferase 3 alpha (DNMT3A), DNA methyltransferase 3 beta (DNMT3B), and signal transducer and activator of transcription 3 (STAT3) in NDEs was significantly decreased in the MBSR group. We also found that intracerebroventricular injection of a miR-29c mimic into 5xFAD mice prevented cognitive decline as well as neuronal loss in the subiculum area by down-regulating DNMT3A and STAT3 in the hippocampus. The results of the present study suggest that MBSR can prevent neuronal loss and cognitive impairment in elderly people by increasing the neuronal expression of miR-29c.