R. Lories, I. Derese, F. Luyten
Feb 17, 2005
Arthritis Research & Therapy
Mitogen-activated protein kinases (MAPKs) are important effector enzymes of different molecular signaling cascades with critical roles in inflammation, in particular in the induction and downstream effects of tumor necrosis factor (TNF) alpha and IL-1. Inhibition of the MAPK signaling cascades has been identified as a potential therapeutic target in chronic arthritis. Little is known about the activation and extent of MAPK signaling in the synovium of patients with psoriatic arthritis. We studied phosphorylation of the three common MAPKs (p38, extracellular regulating kinase [ERK] and C-jun-N-terminal kinase [JNK]) in psoriatic arthritis and the effect of anti-TNF therapy on their activation.