Mononuclear copper(II) nitrato complexes with methyl-substituted 4-nitropyridine N-oxide. Physicochemical and cytotoxic characteristics.

doi:10.1016/j.jinorgbio.2009.10.016

Paper

DOI: 10.1016/j.jinorgbio.2009.10.016

Mononuclear copper(II) nitrato complexes with methyl-substituted 4-nitropyridine N-oxide. Physicochemical and cytotoxic characteristics.

Published Feb 1, 2010 · A. Puszko, Anna Krojcer, M. Pełczyńska

Journal of inorganic biochemistry

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Abstract

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In Vitro Study

Study Snapshot

Copper(II) nitrato complexes with methyl-substituted 4-nitropyridine N-oxide show significant anti-proliferative activity against MCF-7 and SW-707 human cancer cell lines, with a reciprocal relationship between activity and methyl group number.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

DOI: 10.1002/RECL.19510700705

The directive influence of the N-oxide group during the nitration of derivatives of pyridine-N-oxide†

The nitration of pyridine-N-oxide derivatives with bromine, ethoxy, or methyl groups does not influence the course of nitration, even with 2-ethoxypyridine-N-oxide.

2010·11citations·H. J. Hertog et al.·Recueil des Travaux Chimiques des Pays-Bas

Recueil des Travaux Chimiques des Pays-Bas

DOI: 10.1016/J.POLY.2009.02.006

Characterization, nucleolytic, cytotoxic and antibacterial property of tetrakis(μ-4-chloro-2-nitrobenzoato-κ2O,O′)bis[aquacopper(II)], tetrakis(μ-2-chloro-6-fluorobenzoato-κ2O,O′)bis[aquacopper(II)] and tetrakis(μ-2-chlorobenzoato-κ2O,O′)bis[aquacopper(II)]

Tetrakis(-4-chloro-2-nitrobenzoato-2O,O′)bis[aquacopper(II)] shows potent anticancer activity and antibacterial activity against Gram negative bacteria Enterobacter aerogenes.

2009·11citations·Eng-Khoon Lim et al.·Polyhedron

Polyhedron

DOI: 10.1039/B712656P

Antitumour metal compounds: more than theme and variations.

Antitumor metal compounds using metals other than platinum show promise for broadening molecular mechanisms of action and potential indications, while minimizing adverse side effects.

2008·748citations·M. Jakupec et al.·Dalton transactions

Dalton transactions

DOI: 10.1007/S11243-004-2257-2

Ligation of alkoxymethylimidazoles towards cadmium(II) and zinc(II). X-ray, spectroscopic, thermal and potentiometric investigation

Alkoxymethylimidazole complexes with cadmium(II) prefer octahedral coordination, while zinc(II) forms both tetrahedral and octahedral species, with a novel solid-state compound showing slightly distorted

2005·8citations·B. Barszcz et al.·Transition Metal Chemistry

Transition Metal Chemistry

DOI: 10.1016/J.JINORGBIO.2004.09.012

Synthesis, characterization, and cytotoxic activity of copper(II) and platinum(II) complexes of 2-benzoylpyrrole and X-ray structure of bis[2-benzoylpyrrolato(N,O)]copper(II).

Copper(II) and platinum(II) complexes of 2-benzoylpyrrole show cytotoxic activity, while copper(II) complexes do not cause cell death at 10 microM concentration.

2004·8citations·S. Rubino et al.·Journal of inorganic biochemistry

Journal of inorganic biochemistry

Citations

DOI: 10.3390/molecules28020731

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2023·0citations·F. Garci et al.·Molecules

Molecules

DOI: 10.3390/INORGANICS9020009

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2021·15citations·María R. Rodríguez et al.·Inorganics

Inorganics

DOI: 10.1016/J.POLY.2012.09.060

Structure–activity relationship disturbed by a solvolytic process: Study on the [Cu(II)-4-nitropyridine N -oxide derivative] system

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2013·1citation·A. Puszko et al.·Polyhedron

Polyhedron

DOI: 10.1016/j.jinorgbio.2011.05.001

Systematic coordination chemistry and cytotoxicity of copper(II) complexes with methyl substituted 4-nitropyridine N-oxides.

Copper(II) complexes with methyl substituted 4-nitropyridine N-oxides show strong cytotoxic activity against human cancer cell lines, with the best results found for complexes without substituents or with one methyl group.

2011·10citations·A. Puszko et al.·Journal of inorganic biochemistry

Journal of inorganic biochemistry

DOI: 10.1007/S11224-009-9552-7

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Copper(II) acetate complex with 3-methyl-4-nitropyridine-N-oxide shows fast kinetic exchange and metal-metal interactions, with new bands at 16,000 and 24,000 cm1 tentatively assigned to metal-metal interactions and solid state effects.

2010·10citations·Zbigniew Staszak et al.·Structural Chemistry

Structural Chemistry

DOI: 10.1016/j.ica.2010.03.050

Aromatic N-oxide bridged copper(II) coordination polymers: Synthesis, characterization and magnetic properties

Aromatic N-oxide bridged copper(II) coordination polymers exhibit strong antiferromagnetic interactions within paddle wheel units and weak interactions between units.

2010·26citations·R. Sarma et al.·Inorganica Chimica Acta

Inorganica Chimica Acta

DOI:

COPPER(II) COMPLEXES AS IN VITRO ANTICANCER AGENTS AGAINST HUMAN BREAST CANCER MCF-7 CELL LINE: A REVIEW

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