Paper
Morning blood pressure surge: pathophysiology, clinical relevance and therapeutic aspects
Published May 24, 2018 · G. Parati, V. Guida, A. Grillo
Integrated Blood Pressure Control
70
Citations
4
Influential Citations
Abstract
Morning hours are the period of the day characterized by the highest incidence of major cardiovascular events including myocardial infarction, sudden death or stroke. They are also characterized by important neurohormonal changes, in particular, the activation of sympathetic nervous system which usually leads to a rapid increase in blood pressure (BP), known as morning blood pressure surge (MBPS). It was hypothesized that excessive MBPS may be causally involved in the pathogenesis of cardiovascular events occurring in the morning by inducing hemodynamic stress. A number of studies support an independent relationship of MBPS with organ damage, cerebrovascular complications and mortality, although some heterogeneity exists in the available evidence. This may be due to ethnic differences, methodological issues and the confounding relationship of MBPS with other features of 24-hour BP profile, such as nocturnal dipping or BP variability. Several studies are also available dealing with treatment effects on MBPS and indicating the importance of long-acting antihypertensive drugs in this regard. This paper provides an overview of pathophysiologic, methodological, prognostic and therapeutic aspects related to MBPS.
Very Rigorous Journal
Highly CitedMorning blood pressure surge (MBPS) is associated with increased risk of major cardiovascular events and should be treated with long-acting antihypertensive drugs.
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