N-Fluorobenzenesulfonimide was used for the first time as a catalyst to carry out the three-component synthesis of isoquinuclidines with the use of various cyclohexenone (1), benzaldehydes (2), and anilines (3). The yields up to 80% and the endo/exo stereoselectivity ratios up to 19:81 were achieved.

N-Fluorobenzenesulfonimide effectively catalyzes the three-component synthesis of isoquinuclidines with up to 80% yield and 19:81 endo/exo stereoselectivity ratio.

Paper

N‐Fluorobenzenesulfonimide as Catalyst for the Three‐Component Synthesis of Isoquinuclidines

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