Paper
N-acetylcysteine (NAC) in neurological disorders: mechanisms of action and therapeutic opportunities
Published Jan 13, 2014 · Reza Bavarsad Shahripour, M. Harrigan, A. Alexandrov
Brain and Behavior
Q2 SJR score
345
Citations
8
Influential Citations
Abstract
There is an expanding field of research investigating the benefits of medicines with multiple mechanisms of action across neurological disorders. N‐acetylcysteine (NAC), widely known as an antidote to acetaminophen overdose, is now emerging as treatment of vascular and nonvascular neurological disorders. NAC as a precursor to the antioxidant glutathione modulates glutamatergic, neurotrophic, and inflammatory pathways.
Study Snapshot
NAC shows potential as a treatment for vascular and nonvascular neurological disorders by modulating glutamatergic, neurotrophic, and inflammatory pathways.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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