Nanotoxicity in Systemic Circulation and Wound Healing.
M. Bakshi
May 23, 2017
Citations
37
Citations
Journal
Chemical research in toxicology
Full text
Semantic Scholar
Key Takeaway Key Takeaway: Coating nanomaterials with biocompatible molecules significantly reduces their nanotoxicity, promoting their use in systemic circulation and wound healing dressings.
Abstract
Nanotoxicity of nanomaterials is an important issue in view of their potential applications in systemic circulation and wound healing dressing. This account specifically deals with several characteristic features of different nanomaterials which induce hemolysis and how to make them hemocompatible. The shape, size, and surface functionalities of naked metallic as well as nonmetallic nanoparticles surfaces are responsible for the hemolysis. An appropriate coating of biocompatible molecules dramatically reduces hemolysis and promotes their ability as safe drug delivery vehicles. The use of coated nanomaterials in wound healing dressing opens several new strategies for rapid wound healing processes. Properly designed nanomaterials should be selected to minimize the nanotoxicity in the wound healing process. Future directions need new synthetic methods for engineered nanomaterials for their best use in nanomedicine and nanobiotechnology.