Paper
N-Demethylsinomenine, an active metabolite of sinomenine, attenuates chronic neuropathic and inflammatory pain in mice
Published Feb 3, 2021 · Zhiyong Zhou, Nanqing Qiu, Yuntao Ou
Scientific Reports
Q1 SJR score
12
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0
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Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Non-RCT
Animal Study
Rigorous JournalStudy Snapshot
N-demethylsinomenine effectively reduces chronic neuropathic and inflammatory pain in mice, suggesting it may be a useful novel pharmacotherapy for chronic pain control.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Full text analysis coming soon...
References
Metabolic mechanism and anti-inflammation effects of sinomenine and its major metabolites N-demethylsinomenine and sinomenine-N-oxide.
Sinomenine (SIN) undergoes both enzymatic and non-enzymatic cyclic metabolism, acting as a predominant anti-inflammation compound, while its major metabolite, sinomenine-N-oxide (SNO), induces ROS production.
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Citations
N‐Demethylsinomenine Relieves Neuropathic Pain in Male Mice Mainly via Regulating α2‐Subtype GABAA Receptors
N-Demethylsinomenine (NDSM) relieves neuropathic pain in male mice primarily through regulating 2 subtype GABAA receptors and inhibiting neuroinflammation.
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CNS Neuroscience & Therapeutics
Rapid Characterization of the Potential Active of Sinomenine in Rats by Ultra-High-Performance Liquid Chromatography-Quadrupole-Exactive Orbitrap Mass Spectrometry and Molecular Docking.
Sinomenine's anti-inflammatory properties are influenced by its metabolites M28, M36, and M59, which can be identified using ultra-high-performance liquid chromatography-quadrupole-exactive Orbitrap mass spectrometry and molecular docking.
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Journal of separation science
N-demethylsinomenine metabolite and its prototype sinomenine activate mast cells via MRGPRX2 and aggravate anaphylaxis
The M-3 metabolite can activate mast cells synergistically with its prototype sinomenine via MRGPRX2 and aggravate anaphylaxis, providing insights into drug safety.
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Traditional Chinese medicine, particularly compound prescriptions and acupuncture, shows significant clinical efficacy in treating neuropathic pain.
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Sinomenine-related compounds show potential in treating various cancers, inflammation, and neuroprotection, with potential clinical applications in cancer treatment and rheumatic arthritis treatment.
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Molecules
Investigation of preclinical pharmacokinetics of N-demethylsinomenine, a potential novel analgesic candidate, using an UPLC-MS/MS quantification method
N-Demethylsinomenine shows linear pharmacokinetics after intravenous or intragastric administration in rats, with rapid elimination and extensive tissue distribution.
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Isoquinoline alkaloids show potential neuroprotective effects, potentially improving symptoms and prognosis in neurodegenerative diseases like cerebral ischemia, Alzheimer's, and Parkinson's.
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