Neonicotinoids and Other Insect Nicotinic Receptor Competitive Modulators: Progress and Prospects.

doi:10.1146/annurev-ento-020117-043042

Paper

Neonicotinoids and Other Insect Nicotinic Receptor Competitive Modulators: Progress and Prospects.

Published Jan 11, 2018 · J. Casida

Annual review of entomology

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224

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4

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Abstract

Neonicotinoids (neonics) are remarkably effective as plant systemics to control sucking insects and for flea control on dogs and cats. The nitroimines imidacloprid, clothianidin, thiamethoxam, and dinotefuran are the leaders among the seven commercial neonics that also include the nitromethylene nitenpyram, the nitromethylene-derived cycloxaprid, and the cyanoimines acetamiprid and thiacloprid. Honey bees are highly sensitive to the nitroimines and nitromethylenes, but the cyanoimines are less toxic. All neonics are nicotinic acetylcholine receptor (nAChR) agonists with a common mode of action, target-site cross-resistance, and much higher potency on insect than mammalian nAChRs at defined binding sites. The structurally related sulfoximine sulfoxaflor and butenolide flupyradifurone are also nAChR agonists, and the mesoionic triflumezopyrim is a nAChR competitive modulator with little or no target-site cross-resistance. Some neonics induce stress tolerance in plants via salicylate-associated systems. The neonics in general are readily metabolized and, except for pollinators, have favorable toxicological profiles.

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Study Snapshot

Neonicotinoids effectively control sucking insects and fleas on dogs and cats, with promising toxicological profiles and readily metabolized properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Neonicotinoids and Other Insect Nicotinic Receptor Competitive Modulators: Progress and Prospects.

References

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