NEUROLOGIC FEATURES OF PERNICIOUS ANEMIA

doi:10.1001/JAMA.1932.02740600004002

Paper

NEUROLOGIC FEATURES OF PERNICIOUS ANEMIA

Published Aug 20, 1932 · R. H. Young

JAMA

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Abstract

Studies of pernicious anemia have shown the presence of a wide variety of associated lesions in the central nervous system. As early as 1880, Little 1 described cephalalgia, vertigo, syncope, neuralgic pains and mental depression, along with other symptoms of pernicious anemia. The exhaustive work of Russel, Batten and Collier 2 followed that of Lichtheim, 3 Putnam 4 and Dana 5 in the early description of the spinal cord changes. Certain of the lesions described by the former authors have not received mention since. Barrett 6 and, particularly, Woltman 7 have called attention to the cerebral changes. Bastianelli, 8 Putnam and Taylor 9 and others have reported optic atrophy in association with penicious anemia. The sensory changes have been described by many authors, but the work of Hamilton and Nixon 10 is an excellent review of the subject and, in addition, reports pathologic changes in the peripheral nerves. A recent

Study Snapshot

Key takeawayPernicious anemia is associated with various central nervous system lesions, including optic atrophy, cerebellar atrophy, and peripheral nerve changes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

NEUROLOGIC FEATURES OF PERNICIOUS ANEMIA

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