N-Methyl-2-[4-(2-methylpropyl)phenyl]-3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)benzamide; one of a class of novel benzenesulphonamides which are orally-active, ETA-selective endothelin antagonists

doi:10.1016/S0960-894X(97)00228-X

Paper

DOI: 10.1016/S0960-894X(97)00228-X

N-Methyl-2-[4-(2-methylpropyl)phenyl]-3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)benzamide; one of a class of novel benzenesulphonamides which are orally-active, ETA-selective endothelin antagonists

Published Jun 3, 1997 · A. Mortlock, C. Bath, R. Butlin

Bioorganic & Medicinal Chemistry Letters

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

N-Methyl-2-[4-(2-methylpropyl)phenyl]-3-(3-methoxy-5-methylpyrazin-2-ylsulfamoyl)benzamide is a novel ETA-selective endothelin antagonist with high affinity

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Citations

DOI: 10.2533/chimia.2016.420

The Discovery of Macitentan - A Standard Medicinal Chemistry Program?

Macitentan's discovery was driven by tailoring a medicinal chemistry program to optimize in vivo efficacy and safety, leading to a potent dual endothelin receptor antagonist for treating pulmonary arterial hypertension.

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Chapter 6.2 Six-membered ring systems

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