Non-carboxylic antiinflammatory compounds. III. N-(4,6-Dimethylpyridin-2-yl)arylcarboxamides and arylthiocarboxamides acting as brain edema inhibitors

doi:10.1016/0223-5234(96)88310-3

Paper

Non-carboxylic antiinflammatory compounds. III. N-(4,6-Dimethylpyridin-2-yl)arylcarboxamides and arylthiocarboxamides acting as brain edema inhibitors

Published 1995 · J. Robert, S. Robert-Piessard, J. Courant

European Journal of Medicinal Chemistry

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18

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Abstract

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Study Snapshot

N-(4,6-dimethylpyridin-2-yl)arylcarboxamides and arylthiocarboxamides effectively inhibit brain edema, with two showing greater potency than dexamethasone after intravenous administration.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

Non-carboxylic antiinflammatory compounds. III. N-(4,6-Dimethylpyridin-2-yl)arylcarboxamides and arylthiocarboxamides acting as brain edema inhibitors

References

cPLA2 is phosphorylated and activated by MAP kinase

Isosterism and Bioisosterism Case Studies with Muscarinic Agonists

Non-acidic anti-inflammatory compounds: activity of N-(4,6-dimethyl-2-pyridinyl) benzamides and derivatives

Non-acidic antiinflammatory compounds II. Synthesis and activity of 6-amino-2,4-lutidine derivatives

Citations

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This study presents a convenient and mild palladium-catalyzed double carbonylation procedure for the synthesis of N-substituted phthalimides and thalidomide in excellent yields.

Synthesis of Some Novel Benzoxazolinonylcarboxamides as Potential Anti-Inflammatory Agents

New 2(3H)-benzoxazolinonylcarboxamides were synthesized as potential anti-inflammatory agents using Friedel-Crafts acylation of 2(3H)-benzoxazolone derivatives with oxalyl chloride and acety

RP-HPLC LIPOPHILICITY STUDIES FOR SOME (HETERO)ARYLAMIDES DERIVED FROM 2-AMINO 4,6-DIMETHYL PYRIDINE: INTRODUCTION OF AN HYDROGEN-BOND DESCRIPTOR

RP-HPLC measurements with a variable hydrogen-bond donor enhance the goodness of fit for estimating lipophilicity values for 23 substituted (hetero)arylcarboxamides derived from 2-amino 4,6-dimethyl pyridine, providing estimates for their anti-inflammatory and anti-cho

Synthesis and characterization of 3-thiophene carboxamides containing a pyridine ring: structure, electrochemistry, and complexation

New thiophene amides with a pyridine ring can undergo electropolymerization when tuned by introducing an electron-withdrawing group on the pyridine ring.