A NOTE: Ortho‐Phthalaldehyde: proposed mechanism of action of a new antimicrobial agent

doi:10.1046/j.1472-765x.2000.00817.x

Paper

A NOTE: Ortho‐Phthalaldehyde: proposed mechanism of action of a new antimicrobial agent

Published Oct 1, 2000 · C. Simons, S.E Walsh, J. Maillard

Letters in Applied Microbiology

Q3 SJR score

67

Citations

3

Influential Citations

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Abstract

Ortho‐phthalaldehyde (OPA) is a new aromatic dialdehyde antimicrobial agent, the mechanism of action of which has been little studied. The aims of this paper are to examine what is currently known about its mechanism of action, to compare the action with that of a widely investigated aliphatic dialdehyde, glutaraldehyde (GTA), and to put forward a hypothesis that would, in the light of current knowledge, explain how OPA inactivates micro‐organisms, including GTA‐resistant Mycobacterium chelonae.

Study Snapshot

Ortho-phthalaldehyde (OPA) shows potential as an antimicrobial agent by inactivating microorganisms, including GTA-resistant Mycobacterium chelonae, through a similar mechanism of action to glutaraldehyde.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Paper

A NOTE: Ortho‐Phthalaldehyde: proposed mechanism of action of a new antimicrobial agent

References

Studies on the mechanisms of the antibacterial action of ortho‐phthalaldehyde

Ortho-phthalaldehyde (OPA) acts as an antibacterial agent by reacting with primary amino acids and stabilizing the outer membrane and cell walls of bacteria, but its lethal action may not be fully explained by this mechanism.

Ortho‐phthalaldehyde: a possible alternative to glutaraldehyde for high level disinfection

Ortho-phthalaldehyde (OPA) is effective against glutaraldehyde-resistant mycobacteria and a viable alternative to glutaraldehyde for high-level disinfection, with coat-defective spores being more susceptible.

Reduced glutaraldehyde susceptibility in Mycobacterium chelonae associated with altered cell wall polysaccharides.

Glutaraldehyde-resistant Mycobacterium chelonae strains show altered cell wall polysaccharides, resulting in reduced susceptibility to disinfectants and increased surface hydrophobicity.

Glutaraldehyde: Current Status and Uses

Glutaraldehyde is a valuable compound for high-level disinfection in endoscopy units, despite its toxicity for medical staff.

In-hospital evaluation of orthophthalaldehyde as a high level disinfectant for flexible endoscopes☆

OPA is an effective high-level disinfectant for flexible endoscopes, achieving a ≥5 LOG10 reduction in bacterial load and remaining stable for up to 14 days.

Citations

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Disinfectants from the group of oxidizing agents, TA, and PHMG show promising potential in combating microbial biofilms, while ADBAC as an individual compound is ineffective; aldehydes and alcohols are unable to destroy BFs and are ineffective against gram-positive bacteria

Biocides in the Hospital Environment: Application and Tolerance Development.

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